Exercise and calcium in the heart

Cardiomyocyte Ca2+ dictates cardiac contraction via excitation–contraction coupling (ECC) and excitation–transcription coupling. Adaptation to these processes also majorly contributes enhanced contractile function capacity following exercise training. Cytoplasmic release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane L-type channel Ryanodine receptor, as well sarcoplasmic reticulum ATPase. Exercise training increases enhances ECC subprocesses, in a manner that contraction. Also, adaptation further includes myofilament sensitization. Then, there are several aspects linked postexercise cardiomyocyte handling remains speculative inconclusive, but could if proven true be of special importance. This Ca2+-linked muscle-specific gene transcription alter cell architecture size, it scenario whereby cycling adaptations may arrhythmogenicity. These discussed this review article.